yjbI [2017-8-11 16:0:3]

truncated hemoglobin, NO protection

locus: BSU11560

pI: 5.17

mw: 14.98 kDa

protein length: 132 aa

gene length: 396 bp

function: protection against NO, thiol redox homeostasis

product: truncated hemoglobin

essential: no

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.10|Resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)]

Gene

Coordinates: 1,234,510 → 1,234,908

The protein

Catalyzed reaction/ biological activity

• binds sulfide with high affinity [Pubmed|20102180]

Protein family

• protozoan/cyanobacterial globin family (according to Swiss-Prot)

Kinetic information

• K(D) for hydrogen sulfide = 5.0x10(6) M-1 [Pubmed|20102180]

Structure

• [PDB|1UX8]

Expression and Regulation

Operons

• genes: [gene|948BD57CC45915C7CDDB8EF168287533FC514B7C|yjbI]-[gene|87124945A1CBF7990856FBEB9EAD25096DAC0868|yjbH]
  description: [Pubmed|17293416]

  regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [pubmed|29271514], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]

  regulation

  • induced by cell wall stress ([protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]) [pubmed|29271514]

  additional information

  • A [protein|search|ncRNA] is predicted between [gene|138DC46C976BAA18893B70DF040BA1BB2FA0A77C|yizD] and [gene|87124945A1CBF7990856FBEB9EAD25096DAC0868|yjbH] [PubMed|20525796]

Biological materials

Mutant

• MGNA-B155 (yjbI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1154 NBRP B. subtilis, Japan]
• 1A864 ( ''yjbI''::''spec''), [Pubmed| ], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A864&Search=1A864 BGSC]

References

• 17293416,19899166,20102180,22759230,26001125